Polysaccharides and glycolipids of <i>Mycobacterium tuberculosis</i> and their induced immune responses

Tuberculosis (TB) is a chronic infectious disease mainly caused by Mycobacterium tuberculosis (M. tuberculosis). The structures of polysaccharides and glycolipids at M. cell wall vary among different strains, which affect the physiology pathogenesis mycobacteria activating or inhibiting innate acquired immunity. Among them, some components such as lipomannan (LM) lipoarabinomannan (LAM) activate immunity recognizing kinds pattern recognition receptors (PRRs) like Toll-like receptors, while other mannose-capped (ManLAM) could prevent immune responses secretion pro-inflammatory cytokines maturation phagosomes. In addition, many can natural killer T (NKT) cells CD1-restricted to produce interferon-γ (IFN-γ). Furthermore, humoral against components, antibodies LAM, plays role in infection. Cell have potential applications antigens adjuvants for novel TB subunit vaccines.